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Localisation of the breast-ovarian cancer susceptibility gene (BRCAI) on 17q12–21 to an interval of ⩽IcM

✍ Scribed by Dr. Simon A. Smith; Richard A. Dicioccio; Jeffery P. Struewing; Douglas F. Easton; Holly H. Gallion; Hans Albertsen; Sylvie Mazoyer; Bertil Johansson; Elisabeth Steichen-Gersdorf; Mike Stratton; Debbie Ford; Gill Marshall; Raymond L. White; M. Steven Piver; Bruce A. J. Ponder

Book ID
102221903
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
351 KB
Volume
10
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

A breast‐ovarian cancer susceptibility gene, BRCAI, which is responsible for disease in approximately 45% of breast cancer families and most families that contain breast and ovarian cancer, has been assigned by genetic linkage to 17q12–21. Here, we report the analysis of three marker‐disease recombinants in families that contain breast and ovarian cancer, two of which strongly suggest a location for BRCAI telomeric to D17S702, a microsatellite polymorphism, and a third which suggests a location centromeric to EDH17B, the gene encoding estradiol‐17B dehydrogenase. If the interpretation of these recombinants is correct, the results localise BRCA to an interval of ⩽cM. Genes Chrom Cancer 10:71–76 (1994). © 1994 Wiley‐Liss, Inc.

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Linkage mapping in familial breast cance
Linkage mapping in familial breast cancer: Improved localisation of a susceptibility locus on chromosome 17q12-21
✍ D. E. Porter; B. B. Cohen; M. R. Wallace; A. Carothers; C. M. Steel 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 984 KB

## Abstract Fifteen pedigrees with a total of 75 cases of breast cancer, 10 of ovarian cancer and 53 of other cancers have been collected. Polymorphic markers on chromosome 17q have been screened to locate a putative breast‐cancer gene using DNA from relevant individuals within these families. Pair