## Abstract 4βHydroxyandrostenedione (4βOHA) is a specific inhibitor of aromatase activity used for the treatment of breast cancer in postβmenopausal women. Treatment with 4βOHA has been shown to inhibit the peripheral conversion of androstenedione to oestrone and reduce plasma oestrogen concentrat
Local uptake and synthesis of oestrone in normal and malignant postmenopausal breast tissues
β Scribed by A.A Larionov; L.M Berstein; W.R Miller
- Book ID
- 117668329
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 219 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0960-0760
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## An isotopic infusion technique has been used in an attempt to determine the contribution that local, in situ, oestrone synthesis makes to the oestro en content of breast tumours. women with advanced breast cancer for I 2 hr before operation. A t surgery, normal breast and breast tumour biopsy
After infusion of 3H-oestradiol or 'H-oestrone into post-menopausal women with breast cancer, there was a significant uptake of both steroids by breast turnour and normal tissue. The ro ortion of oestrogen present in turnour tissue as H-oestradiol after infusion of 'H-oestradiol (89.4 f 3.5%, mean +