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Local treatment of HPV-induced skin lesions by Cidofovir

✍ Scribed by Ilse Stragier; Dr. Robert Snoeck; Erik De Clercq; Joost J. Van den Oord; Marc Van Ranst; Hugo De Greef

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 152 KB
Volume: 67
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.2213

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi‐treated relapsing HPV‐associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir. J. Med. Virol. 67:241–245, 2002. © 2002 Wiley‐Liss, Inc.

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