Local therapy of carcinoma of the uterine cervix: Part i

✍ Scribed by H. Masuda; Y. Sumiyoshi; Y. Shiojima; T. Suda; T. Kikyo; M. Iwata; N. Fujiyama; Y. Machida; K. Nagai

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 685 KB
• Volume: 48
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19811015)48:8<1899::aid-cncr2820480831>3.0.co;2-k

✦ Synopsis

One-hundred-fifteen patients with cervical cancer were treated hy placing bleomycin, carhazilquinone (Carhoquone), and 5-fluorouracil suppositories in contact with cancer lesions located in the vaginal portion o f the uterus o r hy inserting them into the cervical canal, twice a week, one t o I4 times. The cancer lesions disappeared from 17 to 33 patients with Stage 0 lesions and 9 o f 42 with Stage I A lesions. The remaining lesions were principally found in the deep portion o f the cervical glands and tended to decrease the more often the suppositories were applied. This led to the presumption that if this local therapy had heen carried on longer it would have eradicated even the remaining lesions from the patients with Stage 0 and I A lesions. The optimal per administration dose o f hleomycin appeared to be 30 mg. The use o f Witepsol (Dynamit Nobel Aktiengesellschal't, F.R.G.) suppository hase was accompanied hy frequent adverse reactions t o it, which hindered the local therapy from heing repeated over long periods o f time. A n equal amount mixture ol'hydroxypropyl cellulose and carbomer (Carhopol 934) as the suppository hase was accompanied hy relatively less adberse reactions, wlhich permitted the prolonged local therapy with the suppositories. A trace o f bleomycin was also found in the ovaries, hut i t did not cause microscopically evident histologic changes, nor did it afT'ect the menstrual cycle. I f early cancer can he treated completely by local therapy, it will he useful for the younger patient with early cervical cancer.