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Local TH1 and TH2 responses to parasitic infection in the intestine: regulation by IFN-gamma and IL-4

โœ Scribed by J.F. Urban Jr.; R. Fayer; C. Sullivan; J. Goldhill; T. Shea-Donohue; K. Madden; S.C. Morris; I. Katona; W. Gause; M. Ruff; L.S. Mansfield; F.D. Finkelman


Book ID
117336520
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
519 KB
Volume
54
Category
Article
ISSN
0165-2427

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IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that __Mycobacterium tuberculosis__ (__Mtb__) infection in the absence of IL-10 (IL-10^โˆ’/โˆ’^ mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerat