Local skin rash after intraarticular methyl prednisolone acetate injection in a patient with rheumatoid arthritis
✍ Scribed by Yrjö T. Konttinen; Claes Friman; Erkki Tolvanen; Sakari Reitamo; Eija Johansson
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 309 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Since corticosteroids have an antiinflammatory effect, it is highly improbable that they would cause allergic reactions (1). In one patient, an intraarticular injection of methyl prednisolone acetate caused a generalized maculopapular rash which appeared a few hours after injection and lasted 4 days (2). The patient reported here, on 2 different occasions, developed a local skin rash rich in T lymphocytes and persisting for 2 weeks, beginning 3 days after injection of an intraarticular corticosteroid preparation. The commercial corticosteroid preparation and purified methyl prednisolone acetate alone gave local redness and induration 3 days after intradermal injection. Similar intradermal test results for other purified components (polyethylene glycol 4000, myristyl-gamma-picolinium chloride, and sodium chloride) were negative. These findings suggest that our patient has delayed-type