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Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats

โœ Scribed by Helmy M. Siragy; Chun Xue


Book ID
110109974
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
485 KB
Volume
93
Category
Article
ISSN
0958-0670

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## Abstract Transcription factor Spโ€1 is an important fibrogenic factor that is involved in the pathogenesis of diabetic nephropathy. In this study, we examined the effect of Sp1 decoy oligodeoxynucleotides (ODNs) on the extracellular matrix (ECM) gene expression in cultured rat mesangial cells (RM