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Local reaction and migration of injected silicone gel: Experimental study

✍ Scribed by Cassio Menezes Raposo do Amaral; Valdenize Tiziani; Maria Leticia Cintra; Ingrid Amstalden; Fortunato Badan Palhares

Publisher
Springer
Year
1993
Tongue
English
Weight
352 KB
Volume
17
Category
Article
ISSN
0364-216X

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✦ Synopsis

A study of the local and migratory effects of free silicone gel taken from a mammary prosthesis is reported. Thirty eight Wistar rats were injected in their subcutaneous space with 1 cm s of silicone gel. The animals were sacrificed on day: 3, 7, 15, 30, 60, 180, 240, 360, 420, 450. The visceral organs (heart, kidneys, lungs, stomach, gonads, liver, pancreas, spleen, intestine), as well as the tissue adjacent to the region of injection, were histologically analyzed. There was no detectable silicone and no damage to the visceral organs based on routine histopathological analysis. The greatest fibrosis was observed at the extremities of the disk formed by the silicone in the subcutaneous space.

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