✦ LIBER ✦

Local protein instability predictive of helper T-cell epitopes

✍ Scribed by Samuel J. Landry

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 470 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01152-3

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✦ Synopsis

Although selectivity at the levels of peptide binding to major histocompatibility complex (MHC) class II and recognition by T cells may partially account for immunodominance patterns, it is clear that differential antigen processing also exerts a strong effect. Here, Sam Landry correlates immunodominant epitopes with nearby structurally unstable segments, as identified by hydrogen-deuterium exchange nuclear magnetic resonance (NMR), and suggests that epitope presentation is directed by preferential proteolytic cleavage at the unstable sites.

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