Local institutional review board (IRB) review of a multicenter trial: Local costs without local context
✍ Scribed by Bernard Ravina; Lisa Deuel; Andrew Siderowf; E. Ray Dorsey
- Book ID
- 101462668
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 77 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Multicenter clinical research involves parallel Institutional Review Board (IRB) reviews based on the premise that local review reflects aspects of the research environment. We examined the costs and effects of local IRB review of the consent and protocol in a multicenter clinical trial in Parkinson disease. Seventy‐six percent of changes to the consent reflected standard institutional language, with no substantive changes to the protocol. The costs of this process exceeded $100,000. These findings support initiatives by the Office of Human Research Protections (OHRP) and the National Cancer Institute (NCI) to facilitate centralized reviews. This may be an opportune time for the National Institute of Neurological Disorders and Stroke (NINDS) to adopt a central review model. ANN NEUROL 2010;67:258–260