β Scribed by Dorthe M. Andresen; John H. Barker; Vibeke E. Hjortdal
No coin nor oath required. For personal study only.
Thrombosis poses a significant problem in microvascular surgery, despite antithrombotic therapy. The purpose of the present study was to investigate whether a topical application of unfractionated heparin is equally efficient as a systemic bolus in avoiding thrombosis. A rat femoral artery model was used. Three different doses of systemic heparin (50, 100, and 200 U/kg) and one dose of locally administered heparin (100 U/ml) were evaluated and compared to a control group receiving isotonic saline. A thrombogenic injury, simulating poor microsurgical technique, was applied to the artery. The thrombus area was visualized by transillumination, and recorded for 60 min on video, for subsequent measurement. In addition, the level of activated partial thromboplastin time (APTT) and of antiβactivated clotting factor X (aXa) was determined. Local heparin significantly reduced thrombus size as compared to isotonic saline and systemic heparin (50 and 100 U/kg). Highβdose systemic heparin (200 U/kg) was equally potent, but local heparin had significantly less influence on the hemostatic parameters.Β© 2002 WileyβLiss, Inc. MICROSURGERY 22:265β272 2002
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