Local hemostatic effects of microcrystalline partially deacetylated chitin hydrochloride

✍ Scribed by Sugamori, Tsuyoshi ;Iwase, Hideaki ;Maeda, Mutsuhiro ;Inoue, Yukio ;Kurosawa, Hisashi

• Book ID: 102654543
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 870 KB
• Volume: 49
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(200002)49:2<225::aid-jbm10>3.0.co;2-v

✦ Synopsis

The hemostatic effects of microcrystalline partially deacetylated chitin hydrochloride (DAC-HCl) were compared with those of cotton and collagen hydrochloride (collagen-HCl). The DAC-HCl had excellent physical properties as a hemostatic agent such as its ability to absorb and retain blood. In canine blood it induced the release of substances involved in the process of platelet activation, such as ␤-thromboglobulin and platelet factor 4, and it also had excellent hemoagglutinative properties. Moreover, in a hemo-static study on bleeding from cancellous bone in canines it exhibited a hemostatic effect comparable to that exhibited by collagen-HCl. Because it also has an intrinsic promotive effect on wound healing, chitin hydrochloride is considered to be a promising hemostatic material.