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Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons

✍ Scribed by Jan Maehlen; Tomas Olsson; Ann Zachau; Lars Klareskog; Krister Kristensson

Book ID: 119107365
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 1008 KB
Volume: 23
Category: Article
ISSN: 0165-5728
DOI: 10.1016/0165-5728(89)90031-3

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Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-.I) treatment led