Local dynamic partial least squares approaches for the modelling of batch processes
β Scribed by N. M. Fletcher; A. J. Morris; G. Montague; E. B. Martin
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 575 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0008-4034
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The application of multivariate statistical projection based techniques has been recognized as one approach to contributing to an increased understanding of process behaviour. The key methodologies have included multiβway principal component analysis (PCA), multiβway partial least squares (PLS) and batch observation level analysis. Batch processes typically exhibit nonlinear, time variant behaviour and these characteristics challenge the aforementioned techniques. To address these challenges, dynamic PLS has been proposed to capture the process dynamics. Likewise approaches to removing the process nonlinearities have included the removal of the mean trajectory and the application of nonlinear PLS. An alternative approach is described whereby the batch trajectories are subβdivided into operating regions with a linear/linear dynamic model being fitted to each region. These individual models are spliced together to provide an overall nonlinear global model. Such a structure provides the potential for an alternative approach to batch process performance monitoring. In the paper a number of techniques are considered for developing the local model, including multiβway PLS and dynamic multiβway PLS. Utilising the most promising set of results from a simulation study of a batch process, the local model comprising individual linear dynamic PLS models was benchmarked against global nonlinear dynamic PLS using data from an industrial batch fermentation process. In conclusion the results for the local operating region techniques were comparable to the global model in terms of the residual sum of squares but for the global model structure was evident in the residuals. Consequently, the local modelling approach is statistically more robust.
π SIMILAR VOLUMES
This paper considers models that are relatively complex considering the extent of the calibration data. Such data frequently arise in chemometric applications, near-infrared spectroscopy (NIRS) being a well-known example. Commonly used models are multiple linear regression (MLR) with variable select
The pharmaceutical process of wet granulation and tableting is described as a two-step process. Besides the process variables of both steps and the composition variables of the powder mixture, the physical properties of the intermediate granules are also used to model the crushing strength and disin