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Local drug delivery with a self-contained, programmable, microfluidic system

✍ Scribed by J. Fiering; M. J. Mescher; E. E. Leary Swan; M. E. Holmboe; B. A. Murphy; Z. Chen; M. Peppi; W. F. Sewell; M. J. McKenna; S. G. Kujawa; J. T. Borenstein


Book ID
106373523
Publisher
Springer
Year
2008
Tongue
English
Weight
328 KB
Volume
11
Category
Article
ISSN
1387-2176

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The objective of this study was to evaluate the pharmacokinetics of paclitaxel in a novel self-microemulsifying drug delivery system (SMEDDS) for improved oral administration with or without P-glycoprotein (P-gp) inhibitors. Methods. Paclitaxel SMEDDS formulation was optimized, in terms of droplet s