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Local delivery of rolipram, a phosphodiesterase-4-specific inhibitor, augments bone morphogenetic protein-induced bone formation

โœ Scribed by Yoshio Tokuhara; Shigeyuki Wakitani; Yuuki Imai; Chizumi Nomura; Masatoshi Hoshino; Koichi Yano; Susumu Taguchi; Mitsunari Kim; Yoshinori Kadoya; Kunio Takaoka


Book ID
106231174
Publisher
Springer
Year
2009
Tongue
English
Weight
369 KB
Volume
28
Category
Article
ISSN
0914-8779

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## Abstract The distribution and staining intensity of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 were assessed by immunohistochemistry in ectopic bone induced in Nu/Nu mice by Saosโ€2 cell derived implants. Devitalized Saosโ€2 cells or their extracts can induce endochondral bone formation whe