Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity

Neuronal nitric oxide synthase decreased

Neuronal nitric oxide synthase decreased in the peripheral but not in the central nervous system of diabetic rats

✍ Luigi Rodella; Mauro Bianchi; Giovanni Corsetti; Rita Rezzani; Rossella Bianchi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 928 KB

We explored and compared the diabetic neuralgia induced in streptozotocin-treated rats, monitoring the expression of nitric oxide synthase in several areas of the central nervous system involved in nociceptive transmission, in the spinal ganglia and in the nodose ganglia. The threshold for heat noxi