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Local application of zoledronic acid incorporated in a poly(D,L-lactide)-coated implant accelerates fracture healing in rats

✍ Scribed by Greiner, Stefan H; Wildemann, Britt; Back, David A; Alidoust, Mahtala; Schwabe, Philipp; Haas, Norbert P; Schmidmaier, Gerhard

Book ID
121841507
Publisher
Informa plc
Year
2008
Tongue
English
Weight
601 KB
Volume
79
Category
Article
ISSN
1745-3674

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## Abstract Bisphosphonates such as zoledronic acid (ZOL) are used in diseases associated with osteoclast‐mediated bone loss. However, their antiresorptive activity is partly due to their effect on osteoblasts. Local application might increase the therapeutical fence and their local efficiency and