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Local application of basic fibroblast growth factor into the bone increases bone mass at the applied site in rabbits

✍ Scribed by K. Nakamura; T. Kurokawa; T. Kato; H. Okazaki; K. Mamada; K. Hanada; Y. Hiyama; I. Aoyama; T. Nakamura; M. Tamura

Publisher: Springer
Year: 1996
Tongue: English
Weight: 313 KB
Volume: 115
Category: Article
ISSN: 1434-3916
DOI: 10.1007/bf00420329

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✦ Synopsis

The effect of basic fibroblast growth factor (bFGF) applied locally into the bone under physiological conditions was investigated. An aqueous solution containing Ogg (vehicle), 100 gg or 400 gg recombinant human bFGF was percutaneously applied through a needle into the right ilium in rabbit, and the ilia were harvested 4 weeks after the application. Compared with vehicletreated animals, bone mineral density measured by dualenergy X-ray increased in the 400 gg bFGF group. The width of trabeculae in the bFGF-treated groups was greater than in the vehicle group. These results showed that bFGF applied locally into the bone under physiological conditions affected bone formation, and suggested that such an application might have potential for increasing bone.

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