Local Anesthetics. III. Modifications of β'-4-Methylphenoxyethyl β-N-Methylbenzylamino-ethyl Ether

Modulation of therapeutic antibody effec

Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co-expression of heterologous β1, 4-N-acetylglucosaminyltransferase III and Golgi α-mannosidase II

✍ Claudia Ferrara; Peter Brünker; Tobias Suter; Samuel Moser; Ursula Püntener; Pab 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB 👁 1 views

## Abstract The effector functions elicited by IgG antibodies strongly depend on the carbohydrate moiety linked to the Fc region of the protein. Therefore several approaches have been developed to rationally manipulate these glycans and improve the biological functions of the antibody. Overexpressi