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Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma : A pilot study

✍ Scribed by Philippe Menei; Marie-Claire Venier; Erik Gamelin; Jean-Paul Saint-André; Ghassan Hayek; Eric Jadaud; Dominique Fournier; Philippe Mercier; Gilles Guy; Jean-Pierre Benoit

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 197 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990715)86:2<325::aid-cncr17>3.0.co;2-s

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✦ Synopsis

The authors have developed a new method of drug delivery into the brain using implantable biodegradable microspheres. In this study, this method was used to provide localized and sustained delivery of 5-fluorouracil (5-FU) after the surgical resection of glioblastoma. This antimetabolite and radiosensitizing drug was selected in an attempt to decrease the rate of local recurrence of the tumor.

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