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Local administration of recombinant human antithrombin in a mouse model of peritoneal sepsis

✍ Scribed by S. LOUBELE; H. TEN CATE

Book ID
109151753
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
75 KB
Volume
4
Category
Article
ISSN
1538-7933

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Aggregation of recombinant therapeutic protein products is a concern due to their potential to induce immune responses. We examined the immunogenicity of protein aggregates in commercial formulations of recombinant human growth hormone produced by freeze-thawing or agitation, two stresses commonly e