Lobular carcinoma in situ of the breast(Long-term followup

✍ Scribed by James E. Wheeler; H. T. Enterline; James M. Roseman; Joseph P. Tomasulo; Cheryl H. McIlvaine; William T. Fitts Jr.; James Kirshenbaum

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 924 KB
• Volume: 34
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197409)34:3<554::aid-cncr2820340313>3.0.co;2-7

✦ Synopsis

Ninety-eight women with lobular carcinoma in situ (LICS) of the breast were identified over a 16-year period. Consecutive slide review of all breast material over a 12-year period identified 25 women with LCIS o n biopsy who.did not undergo mastectomy. Only 1 woman (4%) in a complete followup averaging 17.5 years developed ipsilateral invasive carcinoma. Of 32 women with a contralateral breast a t risk, 3 (9.7%) developed infiltrating carcinoma. LCIS was found with infiltrating carcinoma, especially of the lobular (small cell) type, with such frequency as t o indicate a close relationship. However, the risk of subsequent development of infiltrating carcinoma in the breast with biopsyproven LCIS is shown to be substantially less than indicated by previous authors. This suggests that careful and prolonged followup may suffice for the woman whose breast biopsy contains lobular carcinoma in situ.