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LNA: Fast Protein Structural Comparison Using a Laplacian Characterization of Tertiary Structure

✍ Scribed by Bonnel, Nicolas; Marteau, Pierre-Francois


Book ID
117908639
Publisher
IEEE
Year
2012
Tongue
English
Weight
935 KB
Volume
9
Category
Article
ISSN
1545-5963

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## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several β€˜spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations