LN-2 (CD74) : A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma
✍ Scribed by Rossitza Lazova; Robin Moynes; Dennis May; Glynis Scott
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 764 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
RESULTS. LN-2 immunoreactivity did not distinguish between dermatofibroma
Pittsford, New York.
and dermatofibrosarcoma protuberans, both of which showed weak immunoreactivity. In marked contrast, 90% of cases of malignant fibrous histiocytoma showed strong staining for LN-2, whereas the vast majority (90%) of cases of atypical fibroxanthoma were negative or stained only weakly with anti-LN-2 antibodies.
Of the two cases of atypical fibroxanthoma that stained strongly for LN-2, both lesions were ú2 cm in size and extended deep into the subcutaneous fat.
CONCLUSIONS.
Differential expression of the LN-2 antigen by atypical fibroxanthoma and malignant fibrous histiocytoma distinguishes these two lesions and suggests that acquisition of LN-2 positivity may be a marker of tumor progression.