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LMO4 can interact with Smad proteins and modulate transforming growth factor-β signaling in epithelial cells

✍ Scribed by Lu, Z; Lam, K S; Wang, N; Xu, X; Cortes, M; Andersen, B


Book ID
110070341
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
402 KB
Volume
25
Category
Article
ISSN
0950-9232

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A panel of 6 human glioma cell lines was examined for TGF-␤1 responsiveness. U-178 MG and U-251 MG AgCl1 were significantly inhibited by TGF-␤1, while U-343 MGa 31L and U-343 MGa 35L were potently stimulated to proliferate. TGF-␤1 induced endogenous PAI-1 protein synthesis, Smad binding element/(CAG