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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

✍ Scribed by Lizcano, Jose M. (author);Göransson, Olga (author);Toth, Rachel (author);Deak, Maria (author);Morrice, Nick A. (author);Boudeau, Jérôme (author);Hawley, Simon A. (author);Udd, Lina (author);Mäkelä, Tomi P. (author);Hardie, D. Grahame (author);Alessi, Dario R. (author)

Book ID
110027521
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
586 KB
Volume
23
Category
Article
ISSN
0261-4189

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LKB1 is a master kinase that activates 1
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
✍ Lizcano, Jose M. (author);Göransson, Olga (author);Toth, Rachel (author);Deak, M 📂 Article 📅 2004 🏛 Nature Publishing Group 🌐 English ⚖ 586 KB

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MAR