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LKB1 expression is inhibited by estradiol-17β in MCF-7 cells

✍ Scribed by Kristy A. Brown; Kerry J. McInnes; Kiyoshi Takagi; Katsuhiko Ono; Nicole I. Hunger; Lin Wang; Hironobu Sasano; Evan R. Simpson

Book ID
116698697
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
287 KB
Volume
127
Category
Article
ISSN
0960-0760

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## Abstract Early growth response‐1 (__Egr‐1__) is an immediate‐early gene induced by E2 in the rodent uterus and breast cancer cells. E2 induces Egr‐1 mRNA and protein levels in MCF‐7 human breast cancer cells and reporter gene activity in cells transfected with pEgr‐1A, a construct containing the