Cholesterol accumulation and liver cell
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Eduardo P. Beltroy; James A. Richardson; Jay D. Horton; Stephen D. Turley; John
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Article
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2005
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John Wiley and Sons
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English
β 438 KB
Niemann-Pick type C (NPC) disease develops as a result of mutations in the NPC1 gene that encodes a protein involved in the net movement of unesterified cholesterol from the late endosomal/lysosomal compartment to the metabolically active pool of sterol in the cytosol of virtually every cell in the