Severe liver disease is an unusual but potentially fatal complication of sickle-cell disease (SCD). Liver transplantation has been complicated by ongoing SCD and thrombosis. We reviewed 214 pediatric transplants done at our institution from 1990 to 2005. Three patients were transplanted for complica
Liver transplantation for sickle cell hepatopathy
โ Scribed by Lawrence S. Friedman
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 61 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1527-6465
- DOI
- 10.1002/lt.21031
No coin nor oath required. For personal study only.
โฆ Synopsis
Homozygous sickle cell anemia, or sickle cell disease (SCD), affects an estimated 1 in 600 African American children. 1 Hepatomegaly and liver biochemical abnormalities are nearly universal in affected persons; most
๐ SIMILAR VOLUMES
Sickle cell disease (SCD) frequently affects the liver; if acute liver failure (ALF) develops, the only potentially effective therapeutic option is liver transplantation (LT). Only 12 patients for whom LT was performed for SCD-related ALF have been described so far. We report a retrospective series
From October 1993 to February 2007, 25 liver transplantations were performed for hepatoblastoma. Of these 25, 18 children received cadaveric grafts, and 7 received left lateral segments from living donors. Fifteen patients were at level IV in the pretreatment extent of disease staging system for hep
Polycystic liver disease, commonly associated with polycystic kidney disease, can result in massive hepatomegaly and debilitating symptoms. Surgical intervention for symptomatic polycystic liver disease has been associated with significant morbidity and inconsistent long-term palliation; it is more