Liver transplantation for hepatocellular carcinoma: The impact of human immunodeficiency virus infection

✍ Scribed by Eric Vibert; Jean-Charles Duclos-Vallée; Maria-Rosa Ghigna; Emir Hoti; Chady Salloum; Catherine Guettier; Denis Castaing; Didier Samuel; René Adam

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 204 KB
• Volume: 53
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.24062

✦ Synopsis

Liver transplantation (LT) has become an accepted therapy for end-stage liver disease in human immunodeficiency virus-positive (HIV+) patients, but the specific results of LT for hepatocellular carcinoma (HCC) are unknown. Between 2003 and 2008, 21 HIV+ patients and 65 HIV- patients with HCC were listed for LT at a single institution. Patient characteristics and pathological features were analyzed. Univariate analysis for overall survival (OS) and recurrence-free survival (RFS) after LT was applied to identify the impact of HIV infection. HIV+ patients were younger than HIV- patients [median age: 48 (range = 41-63 years) versus 57 years (range = 37-72 years), P < 0.001] and had a higher alpha-fetoprotein (AFP) level [median AFP level: 16 (range = 3-7154 μg/L] versus 13 μg/L (range = 1-552 μg/L), P = 0.04]. There was a trend toward a higher dropout rate among HIV+ patients (5/21, 23%) versus HIV- patients (7/65, 10%, P = 0.08). Sixteen HIV+ patients and 58 HIV- patients underwent transplantation after median waiting times of 3.5 (range = 0.5-26 months) and 2.0 months (range = 0.5-24 months, P = 0.18), respectively. No significant difference was observed in the pathological features of HCC. With median follow-up times of 27 (range = 5-74 months) and 36 months (range = 3-82 months, P = 0.40), OS after LT at 1 and 3 years reached 81% and 74% in HIV+ patients and 93% and 85% in HIV- patients, respectively (P = 0.08). RFS rates at 1 and 3 years were 69% and 69% in HIV+ patients and 89% and 84% in HIV- patients, respectively (P = 0.09). In univariate analysis, HIV status did not emerge as a prognostic factor for OS or RFS.

Conclusion:

Because of a higher dropout rate among hiv+ patients, hiv infection impaired the results of lt for hcc on an intent-to-treat basis but had no significant impact on os and rfs after lt.