𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Liver tissue responses to gelatin and gelatin/chitosan gels

✍ Scribed by Xiaohong Wang; Xin Yu; Yongnian Yan; Renji Zhang

Book ID
102294252
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
493 KB
Volume
87A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

Gelatin and gelatin/chitosan gels, crosslinked using glutaraldehyde, were previously developed as substrates for three‐dimensional cell‐assembly techniques. In this study, the biocompatibility and biodegradation of gelatin and gelatin/chitosan gels were evaluated following implantation in rat livers for periods up to 16 weeks. The two gels were characterized by different inflammatory responses and degradation rates. The gelatin/chitosan gel is more efficient in inducing fibrin formation and vascularization at the implant‐host interface. The degrees of inflammatory reaction for the gelatin/chitosan gel were significantly stronger than the gelatin gel. Advanced biodegradation of the gelatin gels was observed. These data indicate that the gelatin gel has better liver tissue biocompatibility and a faster biodegraded rate than the gelatin/chitosan gel. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

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