Liver size and indices of drug metabolism in alcoholics
✍ Scribed by H. I. Pirttiaho; E. A. Sotaniemi; J. Ahlqvist; U. Pitkänen; R. O. Pelkonen
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 704 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0031-6970
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The clearance of many drugs by the liver is reduced in the elderly, and this accounts, at least in part, for the greater frequency of adverse drug reactions in this population. Ageing in experimental animals is accompanied by a decline in the activities of certain microsomal monooxygenase enzymes;
## Abstract The drug‐metabolizing enzymes of olfactory and respiratory epithelium of cattle were determined. The data of nasal tissues were compared to those of bovine liver. Both oxidative and nonoxidative enzyme activities were investigated. Many compounds including testosterone were used as subs