✦ LIBER ✦

Liver regeneration

✍ Scribed by George K. Michalopoulos

Book ID: 102313307
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 445 KB
Volume: 213
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21172

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✦ Synopsis

Abstract

Liver regeneration after partial hepatectomy is a very complex and well‐orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks of stimulation and inhibition of growth related signals. Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. In situations when hepatocytes or biliary cells are blocked from regeneration, these cell types can function as facultative stem cells for each other. J. Cell. Physiol. 213: 286–300, 2007. © 2007 Wiley‐Liss, Inc.

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