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Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats

✍ Scribed by Chobert, Marie-Noële; Couchie, Dominique; Fourcot, Agnès; Zafrani, Elie-Serge; Laperche, Yannick; Mavier, Philippe; Brouillet, Arthur


Book ID
121851606
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
1019 KB
Volume
92
Category
Article
ISSN
0023-6837

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We have shown, using the proline:ornithine dual label method, that in normal rats, hepatocytes contribute in vivo about 80 to 90% of the newly synthesized hepatic collagen. In order to quantify the contribution of hepatocytes and nonparenchymal cells to collagen synthesis in vivo in hepatic fibrogen