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Liver microsomal hydroxylating system in mice with the toxic form of influenza

โœ Scribed by N. V. Gorbunov; A. P. Volgarev; N. O. Bykova; M. P. Prozorovskaya


Publisher
Springer US
Year
1992
Tongue
English
Weight
288 KB
Volume
114
Category
Article
ISSN
0007-4888

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Metabolism of the mesoionic compound (MI
โœ Silvia Romรฃo; Silvia M. S. C. Cadena; Juliana C. Amorim; Stelia C. Mรฉndez-Sรกnche ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 528 KB

## Abstract The mesoionic derivative 4โ€phenylโ€5โ€[4โ€nitrocinnamoyl]โ€1,3,4โ€thiadiazolylโ€2โ€phenylamine chloride (MIโ€D) has antitumoral and antiโ€inflammatory effects. In this study, we present aspects of its metabolism and toxicity in mice. MIโ€D was metabolized __in vitro__ by liver microsome, generati