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Liver lipid peroxidation and glutathione-related defence enzyme systems in mice treated with paracetamol

✍ Scribed by Gül Özdemirler; Gülçin Aykaç; Müjdat Uysal; Hikmet Öz

Book ID
102291244
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
271 KB
Volume
14
Category
Article
ISSN
0260-437X

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✦ Synopsis

Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg-' i.p.). Furthermore, it has been determined that cytosolic glutathione Stransferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-hr activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities. In this way, these glutathione-related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.

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