Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury
✍ Scribed by C Peralta; A Serafin; L Fernández-Zabalegui; Z.Y Wu; J Roselló-Catafau
- Book ID
- 117233535
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 61 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0041-1345
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Ischemic preconditioning of remote organs (RIPC) reduces liver ischemia/reperfusion (IR) injury in the rabbit and rat. Mice are the only species available with a large number of transgenic strains. This study describes development and validation of a mouse model of hindlimb RIPC that attenuates live
Ischemia and reperfusion lead to injury of the liver. Ischemia-reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment str