Liver function and lactate metabolism in the ill surgical patient

✍ Scribed by G. Royle; M. Kettlewell

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 234 KB
• Volume: 65
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800650921

✦ Synopsis

Abstract

Liver function and lactate metabolism were investigated in non-shocked, severely ill surgical patients. Fasting venous blood lactate concentration was increased and plasma liver function tests were abnormal in ill patients compared with controls. III patients were glucose-intolerant and blood lactate changes following intravenous glucose infusion were similar in both ill and control patients. Blood lactate half-life was increased in ill patients following a sodium L-lactate infusion, suggesting that the increased fasting lactate concentration may have been due to decreased hepatic removal rather than to increased peripheral production of lactate.