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Liver-Derived Insulin-Like Growth Factor I (IGF-I) Is the Principal Source of IGF-I in Blood but Is Not Required for Postnatal Body Growth in Mice

✍ Scribed by Klara Sjögren, Jun-Li Liu, Kristina Blad, Stanko Skrtic, Olle Vidal, Ville Wallenius, Derek LeRoith, Jan Törnell, Olle G. P. Isaksson, John-Olov Jansson and Claes Ohlsson

Book ID: 123641972
Publisher: National Academy of Sciences
Year: 1999
Tongue: English
Weight: 887 KB
Volume: 96
Category: Article
ISSN: 0027-8424
DOI: 10.2307/48012

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## Abstract Integrin receptors bind extracellular matrix proteins, and this link between the cell membrane and the surrounding matrix may translate skeletal loading to biologic activity in osteoprogenitor cells. The interaction between integrin and growth factor receptors allows for mechanically in