Liver carbamylphosphate synthetases
β Scribed by M.A. Grillo; G.G. Pinna
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 303 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0020-711X
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Carbamylphosphate synthetase 1 (E.C. 6.3.4.16) deficiency is a rare autosomal recessive disorder of the urea cycle that can result in severe neonatal hyperammonemia. Since the genomic structure of the CPS1 gene was not yet elucidated, mutation detection was performed by analysis of transcripts in th
Aminoacyl-tRNA synthetases from rat-liver cytoplasm were fractionated into two groups, characterized by their sedimentation coefficients of about 20S and 5S, respectively. These two groups of synthetases could be isolated from postmicrosomal supernatant either by gradient centrifugation, by gel filt