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Liver biopsy in hepatitis C virus carriers with normal alanine aminotransferase levels

✍ Scribed by Laudio Puoti; Lia Bellis; Riccardo Guarisco

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
41 KB
Volume
50
Category
Article
ISSN
0270-9139

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✦ Synopsis

surface antigen (HBsAg) but also in patients with "resolved" HBV infection. 5,6 In a retrospective analysis of lymphoma patients who were HBsAg-negative and anti-HBV core antigen (anti-HBc) positive, 5 of the 21 patients who received chemotherapy plus rituximab, an anti-CD20 antibody, developed hepatitis; all of them were attributed to HBV reactivation. The actual incidence of HBV reactivation may be even higher. Prospective studies to clarify the actual incidence and risk factors of HBV reactivation after immunotherapy in this patient population are necessary to define the optimal preventive strategy.

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