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Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion

✍ Scribed by Kuppen, PJK; Jonges, LE; van de Velde, CJH; Vahrmeijer, AL; Tollenaar, RAME; Borel Rinkes, IHM; Eggermont, AMM

Book ID: 109837394
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 741 KB
Volume: 75
Category: Article
ISSN: 0007-0920
DOI: 10.1038/bjc.1997.255

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## Background: Isolated limb perfusion (ilp) with tumor necrosis factor alpha (tnf alpha) +/-interferon gamma (ifn gamma) and melphalan in patients with primarily irresectable soft tissue sarcoma is promising in terms of tumor regression and limb salvage. however, the feasibility of radiotherapy in