Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

✍ Scribed by Robert N. Fontaine; Ruanna E. Gossett; Friedhelm Schroeder; Barbara A. O'Toole; Thomas Doetschman; Ann B. Kier

• Publisher: Springer
• Year: 1996
• Tongue: English
• Weight: 454 KB
• Volume: 159
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00420917

✦ Synopsis

The effect of transforming growth factor beta-1 (TGF beta 1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGF beta 1-deficient mice. Homozygous TGF beta 1-deficient 129 x CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGF beta 1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGF beta 1-deficient/immunodeficient C3H mice only. Thus, TGF beta 1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.