✦ LIBER ✦

Liver: An organ with predominant innate immunity

✍ Scribed by Bin Gao; Won-Il Jeong; Zhigang Tian

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 126 KB
Volume: 47
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.22034

No coin nor oath required. For personal study only.

✦ Synopsis

Blood circulating from the intestines to the liver is rich in bacterial products, environmental toxins, and food antigens. To effectively and quickly defend against potentially toxic agents without launching harmful immune responses, the liver relies on its strong innate immune system. This comprises enrichment of innate immune cells (such as macrophages, natural killer, natural killer T, and gammadelta T cells) and removal of waste molecules and immunologic elimination of microorganisms by liver endothelial cells and Kupffer cells. In addition, the liver also plays an important role in controlling systemic innate immunity through the biosynthesis of numerous soluble pathogen-recognition receptors and complement components.

Conclusion:

The liver is an organ with predominant innate immunity, playing an important role not only in host defenses against invading microorganisms and tumor transformation but also in liver injury and repair. recent evidence suggests that innate immunity is also involved in the pathogenesis of liver fibrosis, providing novel therapeutic targets to treat such a liver disorder.

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