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Lithocholic acid downregulates vitamin D effects in human osteoblasts

✍ Scribed by S. Ruiz-Gaspà; N. Guañabens; A. Enjuanes; P. Peris; A. Martinez-Ferrer; M. J. Martinez de Osaba; B. Gonzalez; L. Alvarez; A. Monegal; A. Combalia; A. Parés

Book ID
108713906
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
292 KB
Volume
40
Category
Article
ISSN
0014-2972

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We investigated the effects of vitamin D3 on the signaling pathways by prostaglandin E, (PGE2) in osteoblast-like MC3T3-El cells. The pretreatment with 1,25-dihydroxyvitamin D3 (1 ,25-(OH),D3), an active form of vitamin D3, significantly inhibited cAMP accumulation induced by 10 (LM PGE, in a dose-d