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Lithium triethylborohydride reduction of alkyl methanesulfonate esters

โœ Scribed by Holder, Richard W.; Matturro, Michael G.


Book ID
111654002
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
338 KB
Volume
42
Category
Article
ISSN
0022-3263

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Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity 099:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed. We recently repo