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Lithium Regulates Glycogen Synthase Kinase-3β in Human Peripheral Blood Mononuclear Cells: Implication in the Treatment of Bipolar Disorder

✍ Scribed by Xiaohua Li; Ari B. Friedman; Wawa Zhu; Li Wang; Sherer Boswell; Roberta S. May; Lori L. Davis; Richard S. Jope

Book ID: 119197139
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 296 KB
Volume: 61
Category: Article
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2006.02.027

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## Abstract Glycogen synthase kinase 3β (GSK3β) activity is regulated by phosphorylation processes and regulates in turn through phosphorylation several proteins, including eukaryotic initiation factor 2B (eIF2B). Serine 9 phosphorylation of GSK3β (pGSK3βSer9), usually promoted by activation of the