𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lithium neurotoxicity—the reliability of serum lithium measurements

✍ Scribed by Dr. A. Amdisen

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
353 KB
Volume
5
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Some of the case reports describing presumed lithiumlneuroleptic interactions are considered. Lithium toxicity is proposed as a possible mechanism. The paucity of data provided on the 12-hour serum lithium levels should be noted. Most case reports do not specify the time interval between the last lithium dose and the time of venesection. Also, inadequate consideration seems to have been given to individual pharmacokinetic variability and demonstrates an apparent lack of awareness of the physiological time-course of sub-acute lithium toxicity.

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