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Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

✍ Scribed by Vuk Stambolic; Laurent Ruel; James R. Woodgett


Book ID
114319660
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
221 KB
Volume
6
Category
Article
ISSN
0960-9822

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## Abstract Glycogen synthase kinase 3Ξ² (GSK3Ξ²) activity is regulated by phosphorylation processes and regulates in turn through phosphorylation several proteins, including eukaryotic initiation factor 2B (eIF2B). Serine 9 phosphorylation of GSK3Ξ² (pGSK3Ξ²Ser9), usually promoted by activation of the